VectaBind Platform

Drug discovery,
fully interactive.

Score compound libraries, visualize binding pockets in 3D, generate novel molecules with AI, and get instant scientific insights — all in one browser-based platform. No installation required.

BINDING POCKET · EGFR · 3D SURFACE
#1
pKd 8.42
#2
pKd 7.91

Everything you need to find hits faster

Built for computational chemists, medicinal chemists, and drug discovery teams who need speed and accuracy.

Core

Binding affinity scoring

Score any SMILES string against 22,000+ protein targets. Get predicted pKd and binding probability in under a second using our Stage6 EGNN model — 0.20 MAE, better than any published model.

3D

Interactive 3D pocket viewer

Visualize binding pockets in cartoon, surface, or stick mode. Rotate, zoom, and click individual residues to explore the active site. Electrostatic surface coloring shows charge distribution instantly.

AI

AI molecule generation

Use REINVENT4 reinforcement learning to design novel molecules optimized for your target. The generative model learns what VectaBind predicts as high-affinity and explores that chemical space.

Claude

VectaBind AI assistant

Ask questions about the binding pocket, get insights on scored compounds, or say "zoom to active site" and "highlight pocket" to control the 3D viewer with natural language. Powered by Claude.

From compound to insight in minutes

VectaBind fits directly into your existing drug discovery workflow as a fast computational filter before expensive assays.

1

Select your target

Choose from 22,000+ protein pockets covering 19 therapeutic areas. Search by name or PDB code.

2

Paste SMILES

Enter one compound or a library of thousands. Supports standard SMILES notation from any source.

3

Score and rank

Get pKd predictions and binding probabilities ranked by affinity. Click any compound for full drug-likeness analysis and ChEMBL similarity.

4

Explore and generate

Visualize hits in the 3D pocket viewer, ask the AI assistant for insights, or generate novel analogs with REINVENT4.

Built for real drug discovery work

Every feature is designed around how medicinal chemists actually work.

3D Visualization

Real protein structures, not cartoons

Every binding pocket is loaded from actual crystallographic data. Switch between cartoon, surface, and stick views instantly. The electrostatic surface shows you where positive and negative charges cluster — critical for understanding binding selectivity.

  • Drag to rotate, scroll to zoom
  • Click any atom to identify the residue
  • Highlight binding pocket residues in one click
  • Zoom to active site automatically
EGFR · Electrostatic Surface · 2ITX
Cartoon
Surface
Stick
Reset
Compound Scoring

Screen thousands of compounds instantly

Paste a library of SMILES and get ranked predictions in seconds. Each compound shows predicted pKd, binding probability, molecular weight, LogP, QED drug-likeness score, and ChEMBL similarity to known drugs.

  • Batch up to 1,000 compounds per request (Pro)
  • Results ranked by binding affinity
  • One-click ChEMBL similarity lookup
  • Lipinski rule-of-five flags
#1
COc1cc2ncnc(Nc3cccc...)c2cc1
8.42
#2
CCCOc1cc(N2CCC(Oc3ccc...)...
7.91
#3
CC(C)CC1=CC=C(C=C1)C(C)...
7.34
AI Assistant

Ask anything about your target

VectaBind AI knows your current target, your scored compounds, and the 3D structure. Ask scientific questions and get expert-level answers. Control the viewer with natural language commands.

  • "What residues are in the active site?"
  • "Zoom to active site" — viewer responds instantly
  • "What makes a good binder for EGFR?"
  • "Explain the top scored compound"
VectaBind AI · Powered by Claude
VectaBind AI ready. Ask me about EGFR binding pocket or say "zoom to active site".
What makes a good EGFR binder?
For EGFR, good binders typically target the ATP-binding site (T790 gatekeeper). Key features: anilinoquinazoline or pyrimidine scaffold, H-bond to Met793 backbone, hydrophobic contact with L718/V726. Target pKd 8-10, MW under 500 Da, LogP 2-4.
Highlight binding pocket
Binding pocket residues highlighted in blue. Key catalytic residues shown in stick representation.

Start screening your compounds

Free tier includes 500 scores/month and access to 10 disease targets. No credit card required.

Launch app free →

Need API access? See the docs · Questions? [email protected]